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ARICEPT (donepezil HCl) is a prescription medicine to treat mild Alzheimer’s disease (up to 10 mg/day) and moderate to severe Alzheimer’s disease (up to 23 mg/day). Before starting on ARICEPT 23 mg/day, patients should be on ARICEPT 10 mg/day for at least 3 months. The starting dose of ARICEPT is 5 mg/day and can be increased to 10 mg/day after 4-6 weeks. Please take ARICEPT as prescribed by the doctor.
It was first marketed by Eli Lilly and Company, and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered). In structure, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desosamine), making it a compound very difficult to produce via synthetic methods. |
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